Literature summary extracted from

Billson, H.A.; Harrison, K.L.; Lees, N.P.; Hall, C.N.; Margison, G.P.; Povey, A.C.
Dietary variables associated with DNA N7-methylguanine levels and O6-alkylguanine DNA-alkyltransferase activity in human colorectal mucosa (2009), Carcinogenesis, 30, 615-620.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.1.1.63	DNA containing 6-O-methylguanine + [protein]-L-cysteine	Homo sapiens	-	DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.63	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.1.1.63	colorectal mucosa	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.1.1.63	DNA containing 6-O-methylguanine + [protein]-L-cysteine	-	Homo sapiens	DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.1.1.63	MGMT	-	Homo sapiens
2.1.1.63	O6-alkylguanine DNA-alkyltransferase	-	Homo sapiens

Expression

EC Number	Organism	Comment	Expression
2.1.1.63	Homo sapiens	MGMT activity is significantly higher in the group with the lowest consumption of vegetables than in the group with the greatest vegetable consumption	up

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Release 2023.1 (January 2023)